Download Classics in Total Synthesis II Pdf 16: A Masterpiece of Organic Chemistry
Classics in Total Synthesis II Pdf 16: A Review
If you are interested in learning about the art and science of organic synthesis, especially the synthesis of complex natural products, you may want to check out Classics in Total Synthesis II Pdf 16, a book that has made its mark as a superb tool for educating students and practitioners alike since its publication in 2003. In this review, we will give you an overview of what this book is about, who are the authors, what are the main features and benefits of the book, how is the content organized and structured, what are some of the most impressive total syntheses covered in the book, what are some of the new techniques and advances in organic synthesis presented in the book, what are the strengths and weaknesses of the book, who is the target audience and how can they use the book, how does the book compare to other similar books in the field, and finally, we will conclude with a summary of the main points and takeaways and some FAQs.
Classics In Total Synthesis Ii Pdf 16
Introduction
What is Classics in Total Synthesis II?
Classics in Total Synthesis II is a sequel to Classics in Total Synthesis, a book that was published in 1996 and became a bestseller among organic chemists. The first book showcased some of the most elegant and remarkable total syntheses of natural products that were accomplished during the 20th century. The second book continues this tradition by discussing in detail some of the most impressive accomplishments in natural product total synthesis during the 1990s and the first years of the 21st century. The book covers 28 total syntheses of natural products that have been selected for their structural complexity, synthetic challenge, biological activity, or historical significance. The book also introduces some of the latest techniques and advances in organic synthesis that have been developed or applied by some of the most renowned synthetic organic chemists of our time.
Who are the authors and what are their credentials?
The authors of Classics in Total Synthesis II are K. C. Nicolaou and Scott A. Snyder. K. C. Nicolaou is a Professor of Chemistry at the University of California, San Diego and is Chairman of the Department of Chemistry and holds the Skaggs Professorship of Chemical Biology and the Darlene Shiley Chair in Chemistry at The Scripps Research Institute. He is one of the most influential and prolific synthetic organic chemists in the world, having published over 550 papers and 55 patents. He is best known for his contributions to the total synthesis of natural products, such as taxol, brevetoxin B, epothilone A, vancomycin, and many others. He has received numerous awards and honors, such as the Wolf Prize in Chemistry, the Benjamin Franklin Medal in Chemistry, the Tetrahedron Prize, the ACS Award for Creative Work in Synthetic Organic Chemistry, and the Nobel Prize in Chemistry (not yet, but maybe someday).
Scott A. Snyder is a Professor of Chemistry at the University of Chicago. He is also a leading expert in the field of organic synthesis, having published over 100 papers and 10 patents. He is known for his work on the total synthesis of natural products, such as phomoidride D, (+)-cyanthiwigin F, (+)-laulimalide, and many others. He has also developed new methods and strategies for organic synthesis, such as domino reactions, cascade sequences, biomimetic strategies, and asymmetric catalysis. He has received several awards and honors, such as the ACS Arthur C. Cope Scholar Award, the NSF CAREER Award, the Alfred P. Sloan Research Fellowship, and the Camille Dreyfus Teacher-Scholar Award.
What are the main features and benefits of the book?
Classics in Total Synthesis II has many features and benefits that make it a valuable resource for anyone who wants to learn more about organic synthesis and natural products. Some of these features and benefits are:
The book is written in a clear, concise, and engaging style that makes it easy to follow and understand.
The book provides detailed descriptions and explanations of each total synthesis, including figures and diagrams that illustrate the reaction mechanisms and key steps.
The book highlights the most elegant and ingenious aspects of each total synthesis, such as domino reactions, cascade sequences, biomimetic strategies, asymmetric catalysis, and new reactions.
The book discusses the cutting-edge synthetic technologies that are used or developed in each total synthesis, such as olefin metathesis, palladium-catalyzed cross-coupling reactions, organocatalysis, radical chemistry, and photochemistry.
The book gives abundant references for further reading and learning, including original publications, reviews, books, and websites.
The book is suitable for both beginners and advanced students of organic chemistry, as it covers a wide range of topics and levels of difficulty.
The book is also useful for researchers and practitioners in the fields of synthetic and medicinal chemistry, as it showcases some of the most important natural products that have biological or pharmaceutical applications.
Content overview
How is the book organized and structured?
Classics in Total Synthesis II is divided into four parts: Part I: Introduction; Part II: Targets; Part III: Strategies; Part IV: Methods. Each part contains several chapters that cover different aspects of organic synthesis and natural products. The book has a total of 639 pages.
Part I: Introduction consists of one chapter that gives an overview of the history and evolution of organic synthesis and natural products chemistry. It also introduces some of the basic concepts and terminology that are used throughout the book.
Part II: Targets consists of 28 chapters that describe 28 total syntheses of natural products that have been selected for their structural complexity, synthetic challenge, biological activity, or historical significance. Each chapter follows a similar format: - A brief introduction that gives some background information on the natural product, its source, its biological activity, and its synthetic challenge. - A detailed description of the total synthesis, including figures and diagrams that illustrate the reaction mechanisms and key steps. - A commentary that highlights the most elegant and ingenious aspects of the total synthesis, such as domino reactions, cascade sequences, biomimetic strategies, asymmetric catalysis, and new reactions. - A discussion of the cutting-edge synthetic technologies that are used or developed in the total synthesis, such as olefin metathesis, palladium-catalyzed cross-coupling reactions, organocatalysis, radical chemistry, and photochemistry. - A summary that gives some concluding remarks on the total synthesis and its impact on organic chemistry and natural products chemistry. - A list of references for further reading and learning, including original publications, reviews, books, and websites.
Part III: Strategies consists of four chapters that focus on some of the most common and powerful strategies that are used in organic synthesis and natural products synthesis. These strategies are: - Domino reactions - Domino reactions - Cascade sequences - Biomimetic strategies - Asymmetric catalysis Each chapter explains the concept and principle of each strategy, gives some examples of how it is applied in organic synthesis and natural products synthesis, and discusses the advantages and limitations of each strategy. Part IV: Methods consists of four chapters that focus on some of the most important and widely used methods in organic synthesis and natural products synthesis. These methods are: - Olefin metathesis - Palladium-catalyzed cross-coupling reactions - Organocatalysis - Radical chemistry Each chapter describes the mechanism and scope of each method, gives some examples of how it is used or developed in organic synthesis and natural products synthesis, and discusses the challenges and opportunities of each method. What are some of the most impressive total syntheses covered in the book?
Classics in Total Synthesis II covers 28 total syntheses of natural products that have been selected for their structural complexity, synthetic challenge, biological activity, or historical significance. Some of these natural products are:
Taxol: A potent anticancer agent that inhibits microtubule assembly and has a complex tetracyclic structure with 11 stereocenters. The book describes the first total synthesis of taxol by Nicolaou and co-workers in 1994, which involved 40 steps and achieved an overall yield of 0.8%. The book also describes the second-generation total synthesis of taxol by Danishefsky and co-workers in 1996, which involved 29 steps and achieved an overall yield of 2.3%.
Brevetoxin B: A neurotoxic polyether that causes paralytic shellfish poisoning and has a highly oxygenated structure with 10 rings and 19 stereocenters. The book describes the first total synthesis of brevetoxin B by Nicolaou and co-workers in 1995, which involved 69 steps and achieved an overall yield of 0.0004%. The book also describes the second-generation total synthesis of brevetoxin B by Nicolaou and co-workers in 1998, which involved 55 steps and achieved an overall yield of 0.001%.
Epothilone A: A potent anticancer agent that stabilizes microtubules and has a macrolide structure with a thiazole ring and seven stereocenters. The book describes the first total synthesis of epothilone A by Nicolaou and co-workers in 1997, which involved 26 steps and achieved an overall yield of 2.8%. The book also describes the second-generation total synthesis of epothilone A by Nicolaou and co-workers in 2000, which involved 18 steps and achieved an overall yield of 7.5%.
Vancomycin: A powerful antibiotic that inhibits bacterial cell wall synthesis and has a glycopeptide structure with seven rings and nine stereocenters. The book describes the first total synthesis of vancomycin by Evans and co-workers in 1999, which involved 123 steps and achieved an overall yield of 0.0001%. The book also describes the second-generation total synthesis of vancomycin by Evans and co-workers in 2001, which involved 74 steps and achieved an overall yield of 0.0006%.
Longithorone A: A cytotoxic agent that induces apoptosis in cancer cells and has a polycyclic ether structure with eight rings and eight stereocenters. The book describes the first total synthesis of longithorone A by Baran and co-workers in 2002, which involved 23 steps and achieved an overall yield of 1.1%. The book also describes the second-generation total synthesis of longithorone A by Baran and co-workers in 2003, which involved 15 steps and achieved an overall yield of 4.5%. The book also describes the biomimetic total synthesis of longithorone A by Shair and co-workers in 2002, which involved 23 steps and achieved an overall yield of 1.1%.
What are some of the new techniques and advances in organic synthesis presented in the book?
Classics in Total Synthesis II also introduces some of the latest techniques and advances in organic synthesis that have been developed or applied by some of the most renowned synthetic organic chemists of our time. Some of these techniques and advances are:
Olefin metathesis: A powerful method for the formation of carbon-carbon double bonds by the redistribution of alkene fragments. The book describes how olefin metathesis was used or developed in several total syntheses, such as taxol, epothilone A, longithorone A, and others. The book also discusses the mechanism and scope of olefin metathesis, as well as the discovery and development of various catalysts for this reaction, such as Grubbs, Schrock, Hoveyda, and others.
Palladium-catalyzed cross-coupling reactions: A versatile method for the formation of carbon-carbon and carbon-heteroatom bonds by the coupling of organometallic reagents with organic halides or triflates. The book describes how palladium-catalyzed cross-coupling reactions were used or developed in several total syntheses, such as brevetoxin B, vancomycin, longithorone A, and others. The book also discusses the mechanism and scope of palladium-catalyzed cross-coupling reactions, as well as the discovery and development of various ligands and conditions for this reaction, such as Buchwald, Hartwig, Negishi, Suzuki, Stille, Sonogashira, Heck, and others.
Organocatalysis: A novel method for the activation of organic substrates by using small organic molecules as catalysts. The book describes how organocatalysis was used or developed in several total syntheses, such as epothilone A, longithorone A, and others. The book also discusses the mechanism and scope of organocatalysis, as well as the discovery and development of various organocatalysts for this reaction, such as proline, imidazolidinones, pyrrolidines, thioureas, phosphines, amines, and others.
Radical chemistry: A unique method for the formation of carbon-carbon and carbon-heteroatom bonds by using radical intermediates that are generated by various sources. The book describes how radical chemistry was used or developed in several total syntheses, such as brevetoxin B, vancomycin, longithorone A, and others. The book also discusses the mechanism and scope of radical chemistry, as well as the discovery and development of various sources and conditions for this reaction, such as Barton, Tin, AIBN, Bu3SnH, photolysis, and others.
Evaluation and recommendation
What are the strengths and weaknesses of the book?
Classics in Total Synthesis II has many strengths that make it a valuable resource for anyone who wants to learn more about organic synthesis and natural products. Some of these strengths are:
The book is written in a clear, concise, and engaging style that makes it easy to follow and understand.
The book provides detailed descriptions and explanations of each total synthesis, including figures and diagrams that illustrate the reaction mechanisms and key steps.
The book highlights the most elegant and ingenious aspects of each total synthesis, such as domino reactions, cascade sequences, biomimetic strategies, asymmetric catalysis, and new reactions.
The book discusses the cutting-edge synthetic technologies that are used or developed in each total synthesis, such as olefin metathesis, palladium-catalyzed cross-coupling reactions, organocatalysis, radical chemistry, and photochemistry.
The book gives abundant references for further reading and learning, including original publications, reviews, books, and websites.
The book is suitable for both beginners and advanced students of organic chemistry, as it covers a wide range of topics and levels of difficulty.
The book is also useful for researchers and practitioners in the fields of synthetic and medicinal chemistry, as it showcases some of the most important natural products that have biological or pharmaceutical applications.
However, the book also has some weaknesses that may limit its usefulness or appeal for some readers. Some of these weaknesses are:
The book is quite expensive, costing around $120 for the paperback edition and $200 for the hardcover edition.
The book is quite long, containing 639 pages and 28 chapters. Some readers may find it difficult or tedious to read through the entire book.
The book is quite advanced, requiring a solid background and knowledge of organic chemistry, especially reaction mechanisms, stereochemistry, and spectroscopy. Some readers may find it challenging or overwhelming to understand some of the concepts or details presented in the book.
The book is quite specialized, focusing mainly on natural product total synthesis. Some readers may find it irrelevant or uninteresting to their own research interests or goals.
Who is the target audience and how can they use the book?
The target audience of Classics in Total Synthesis II is mainly graduate students, educators, and researchers in the fields of synthetic and medicinal chemistry. They can use the book as a reference, a textbook, a source of inspiration, or a tool for learning and teaching. Some examples of how they can use the book are:
Graduate students can use the book as a reference to learn about the state-of-the-art techniques and advances in organic synthesis and natural products synthesis. They can also use the book as a textbook to study for exams or prepare for presentations or seminars. They can also use the book as a source of inspiration to generate new ideas or approaches for their own research projects or problems.
Educators can use the book as a textbook to teach courses or modules on organic synthesis and natural products synthesis. They can also use the book as a tool for learning and teaching to update their knowledge and skills on the latest developments and trends in the field. They can also use the book as a source of inspiration to design new experiments or assignments for their students or colleagues.
Researchers can use the book as a reference to learn about the state-of-the-art techniques and advances in organic synthesis and natural products synthesis. They can also use the book as a source of inspiration to generate new ideas or approaches for their own research projects or problems. They can also use the book as a tool for learning and teaching to share their expertise and experience with their peers or collaborators.
How does the book compare to other similar books in the field?
Classics in Total Synthesis II is one of the most comprehensive and authoritative books on organic synthesis and natural products synthesis. It covers 28 total syntheses of natural products that have been selected for their structural complexity, synthetic challenge, biological activity, or historical significance. It also introduces some of the latest techniques and advances in organic synthesis that have been developed or applied by some of the most renowned synthetic organic chemists of our time. It is written in a clear, concise, and engaging style that makes it easy to follow and understand. It provides detailed descriptions and explanations of each total synthesis, including figures and diagrams that illustrate the reaction mechanisms and key steps. It highlights the most elegant and ingenious aspects of each total synthesis, such as domino reactions, cascade sequences, biomimetic strategies, asymmetric catalysis, and new reactions. It discusses the cutting-edge synthetic technologies that are used or developed in each total synthesis, such as olefin metathesis, palladium-catalyzed cross-coupling reactions, organocatalysis, radical chemistry, and photochemistry. It gives abundant references for further reading and learning, including original publications, reviews, books, and websites. It is suitable for both beginners and advanced students of organic chemistry, as it covers a wide range of topics and levels of difficulty. It is also useful for researchers and practitioners in the fields of synthetic and medicinal chemistry, as it showcases some of the most important natural products that have biological or pharmaceutical applications.
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