A Classic Textbook on Digital Circuits and Logic Design by Samuel C. Lee
we also champion projects and experiences that are broader than bio-digital labs and help make our field of work more inclusive by enabling participation by groups currently under-represented in the life-sciences. these projects cover a wide range of topics, from mentorship for underrepresented students, to accessible exhibitions, to more inclusive industry outreach.
Digital Circuits And Logic Design Samuel C Lee Pdf 11
our lab also publishes on a variety of different topics in the bio-digital world. from the design of novel microfluidic and lab robotics platforms, to the use of interactive bio-games for teaching, to the establishment of practice and systems-level bio-digital tools, we aim to make bio-digital work more broadly accessible.
the leaders of our lab use systems that prioritize direct-action over more passive methods, i.e., we use tools that go into action (as opposed to tools that wait for things to happen). we acknowledge the use of an engineers mindset and prefer mass-action to mass-passivity. we are constantly seeking opportunities to apply these principles to problems in our field that we believe could be rectified by a more direct-action approach. this section details several different techniques that emphasize: active hardware, human-centric design, quick prototyping, and iterative evaluation. it is our hope that this results in a larger change within our field.
compared to conventional digital recording and storage technologies, dna tape is a highly scalable and intrinsically ordered system where the precise order of recorded events cannot be easily affected by extrinsic factors such as lossy compression. thus, without any additional processes or devices, dna tape can very easily store, retain and reconstruct any sequence of events, including digital signals that have decayed due to channel effects, or have been obscured by noise. in fact, we found that we could reconstruct digital audio signals embedded in dna as high as a 20% degradation for short sequences (extended data fig. 1e), even when these signals had been largely degraded by being embedded into dna. this makes dna tape extremely attractive in systems where a sensor reads a digital recording, records that recording to tape and then transmits the tape, which is subsequently read by a recipient who can replay the recorded sequence, without knowledge of the underlying digital signals. examples where such a system would be beneficial include distributed sensing and communication applications that can deploy thousands of sensors that collect, record to tape, and transmit the tape before it is ultimately read by another device. we also found that for a given data set, the statistical information captured by dna is effectively independent of sequence coverage and sequence length, and that we could reliably detect and reconstruct data sets containing as few as 50,000 unique sequences with coverages of as low as 0.01 (extended data fig. 5).
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